منابع مشابه
Dial M(RF) for myogenesis.
The transcriptional regulatory network that controls the determination and differentiation of skeletal muscle cells in the embryo has at its core the four myogenic regulatory factors (MRFs) Myf5, MyoD, Mrf4 and MyoG. These basic helix-loop-helix transcription factors act by binding, as obligate heterodimers with the ubiquitously expressed E proteins, to the E-box sequence CANNTG. While all skel...
متن کاملSix1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo.
In mammals, Six5, Six4 and Six1 genes are co-expressed during mouse myogenesis. Six4 and Six5 single knockout (KO) mice have no developmental defects, while Six1 KO mice die at birth and show multiple organ developmental defects. We have generated Six1Six4 double KO mice and show an aggravation of the phenotype previously reported for the single Six1 KO. Six1Six4 double KO mice are characterize...
متن کاملA Design Methodology for Reliable MRF-Based Logic Gates
Probabilistic-based methods have been used for designing noise tolerant circuits recently. In these methods, however, there is not any reliability mechanism that is essential for nanometer digital VLSI circuits. In this paper, we propose a novel method for designing reliable probabilistic-based logic gates. The advantage of the proposed method in comparison with previous probabilistic-based met...
متن کاملAging: Dial M for Mitochondria
A major goal of aging research is to identify interventions that prolong lifespan in distantly related organisms. In recent years, genetic studies in both nematodes and rodents have reported that moderate inactivation of genes important for mitochondrial electron transport chain (ETC) function can promote longevity. We performed an RNAi screen to probe the role of ETC components in modulating l...
متن کاملDial M for Management: Next Generation NoSQL
NoSQL databases offer a powerful and flexible means of querying non-relational data. However, leading NoSQL systems typically achieve high performance goals while minimizing support for traditional data management services and defying the establishment of solid formal models. In particular, the systems generally shun tools and design principles rendered conventional by the long history of RDBMS...
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ژورنال
عنوان ژورنال: FEBS Journal
سال: 2013
ISSN: 1742-464X
DOI: 10.1111/febs.12379